No. While both refer to a kind of medicine abuse, they are not the same thing. Both involve taking dangerously high doses of cough suppressants, but the active ingredient differs. DXM is the active ingredient in over-the-counter medicines. The active ingredient in sizzurp is codeine, which is only available with a prescription. Sizzurp is sometimes referred to as “drank,” “purple drank,” “lean,” or “syrup.” Sizzurp can depress the central nervous and respiratory systems, causing the lungs and heart to stop functioning. Known side effects of codeine abuse can include addiction, nausea, sedation, stomach bleeding, kidney and liver damage, convulsions, hallucinations, depression, tremors and seizures.